With fetal gene therapy you can derive a wide range of possibilities. This has to be a minimal inevaise surgery and on the other hand where you have a complex surgery. This would require a team of medical care at your disposal. This does require a multi-disciplinary approach and communication among all the medical team is a definite must. The fetal pathology might be the cause of the surgery, but you cannot forget about the safety aspect of the mother. The formulation of the surgery plan has to be spot on. The key is to be aware about fetal gene therapy and its implications.
You need to be aware that severe FGR is on the rarer side and there is no cause of alarm. There are a host of genetic disorders which has an impact on new born and this could be varied degree of severity. With the passage of time all these conditions could be pinned down to a single or a couple of genes. These genetic conditions are really rare, but when you go on to add all of them you can point to some degree of genetic disorder. For this reason an increasing number of mothers in the coming years will be aware that their babies are going to have some form of genetic disorder when they are born. With more and more options, the knowledge will increase and this would include intervention and intervening as far as fetal gene therapy evolves.
The medicines of the patients and how you can manage them during the perioperative period? The patients are normally provided prenatal vitamins, and this does not need to be continued in the perioperative period.
When you are going to deliver a gene to an organ or it could be a fetus you might need a vehicle carrier. AAV is the virus that is known to work best, but their carrying capacity is on the lesser side. Through the body only small genes can be developed, but from large genes some form of genetic issues do come up. At this point of time the CRISPR comes into picture. This does go on to work as a form of editing system. In the same manner as you are going to cut and paste documents in MS word with CRISPR you can go on to edit organism’s genome. This does mean concise information about genetic conditions. With this system the gene therapists are in a position where they would be able to edit small fractions of the gene. This is going to incorporate a small portion of the genetic material that you need as it is going to repair the DMD gene that can make a way into the AAV virus. What it does mean would be that CRISPR could take gene therapy to the next level and this is going to apply to the gene therapy that is being delivered to a fetus at this point of time.